The Karakul depression was picked out as the possible impact structure by the study of space images of Tadjikistan. Its striking similarity with some complex impact craters such as Dellen and Gosses Bluff is evident. Our investigations of the Karakul depression in 1987 and 1989-1991 years allowed to determine it as the impact crater with the central uplift. The target of the crater is presented by slightly metamorphosed sedimentary rocks of Paleozoic, intensively folded and intruded with granites during the Gercynian orogeny. The modern structure of north-eastern Pamirs was formed by Alpinian orogeny; the raise of the area in Neogene was about 4000-7000 m.